CAS NO. |
Products Name |
383432-38-0 |
CP-724714 |
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CP-724,714 is a potent, selective inhibitor of HER2/ErbB2 with IC50 of 10 nM, >640-fold selectivity against EGFR, InsR, IRG-1R, PDGFR, VEGFR2, Abl, Src, c-Met etc. |
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917879-39-1 |
MK-2461 |
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MK-2461 is a novel ATP-competitive multitargeted inhibitor of activated c-Met with a mean IC50 of 2.5 nM. |
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871026-44-7 |
TAK-285 |
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TAK-285 is a novel dual HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, >10-fold selectivity for HER1/2 than HER4, less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. |
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1373422-53-7 |
GSK-J1 |
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GSK-J1 is a potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM for human JMJD3 in vitro). |
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945714-67-0 |
FPS-ZM1 |
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FPS-ZM1 is a high-affinity RAGE-specific inhibitor that blocks Aβ binding to the V domain of RAGE with Ki of 25 ± 5 nM in RAGE-transfected CHO cells. |
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1637739-82-2 |
BQU57 |
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BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth similar to depletion of Ral by siRNA. The IC50 for BQU57 of 2.0 μM in H2122 and 1.3 μM in H358. |
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