CAS NO. |
Products Name |
23146-22-7 |
IQ-1S |
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IQ-1S (free acid) is an inhibitor of JNK kinases, with a preference for JNK3. Kd values for IQ-1S binding to JNK 1, 2 and 3 binding are 390, 360 and 87 nM, respectively. |
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861393-28-4 |
A-740003 |
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A-740003 is potent, selective and competitive P2X7 receptor antagonist (IC50 values are 18 and 40 nM for rat and human receptors respectively). |
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1271022-90-2 |
BMS911543 |
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BMS-911543 is a potent and selective small-molecule inhibitor of JAK2, displays potent anti-proliferative and pharmacodynamic (PD) effects in cell lines dependent upon JAK2 signaling. |
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1054543-47-3 |
Apoptozole |
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Apoptozole is an inhibitor of heat shock protein 70 (Hsp70; 65% inhibition at 200 μM) that acts by blocking its ATPase activity. |
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449811-01-2 |
Pamapimod |
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Pamapimod is a novel p38 mitogen-activated protein kinase inhibitor. Pamapimod inhibited p38α and p38β enzymatic activity, with IC50 values of 0.014 ± 0.002 and 0.48 ± 0.04 μM, respectively. Pamapimod is p38 inhibitor with IC50 of 0.06μM in THP-1 cell. |
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293754-55-9 |
T0901317 |
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T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively, inhibits nuclear factor/κB (NF/κB) |
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844499-71-4 |
A-769662 |
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A-769662 is a potent, reversible AMPK activator with EC50 of 0.8 μM, little effect on GPPase/FBPase activity. |
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874911-96-3 |
ZK756326 |
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ZK756326 is a full agonist of CCR8(Chemokine receptor 8) with an IC50 of 1.8 μM, dose-responsively eliciting an increase in intracellular calcium and cross-desensitizing the response of the receptor to CCL1. |
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1821428-35-6 |
AZD0156 |
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AZD0156 is an oral, potent and selective ATM kinase inhibitor, inhibiting the kinase activity of ATM and ATM-mediated signaling, preventing DNA damage checkpoint activation, and disrupting DNA damage repair, inducing tumor cell apoptosis, and leading to cell death in ATM-overexpressing tumor cells. |
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