CAS NO. |
Products Name |
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422513-13-1 |
Hesperadin |
more... |
Hesperadin potently inhibits Aurora B with IC50 of 250 nM. It markedly reduces the activity of AMPK, Lck, MKK1, MAPKAP-K1, CHK1 and PHK while it does not inhibit MKK1 activity in vivo. |
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587850-67-7 |
C7280948 |
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C7280948isInhibitor of histone arginine methyltransferase PRMT1 with IC50 values of 12.75 μM; useful tool in studying epigenetic role of PRMT1. |
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717906-29-1 |
PF-431396 |
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PF-431396 is dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). PF-431396 promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. PF-431396 is used in treatment of osteoporosis. |
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943319-70-8 |
Ponatinib(AP24534) |
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Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM, respectively. |
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123464-89-1 |
PNU282987 |
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PNU-282,987 is a highly selective agonist for the homomeric α7 nicotinic acetylcholine receptor (α7 nAChR). |
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1009820-21-6 |
CX-4945 (Silmitasertib) |
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CX-4945 (Silmitasertib) is a potent and selective inhibitor of CK2 (casein kinase 2) with IC50 of 1 nM, less potent to Flt3, Pim1 and CDK1 (inactive in cell-based assay). Phase 1/2. |
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202590-98-5 |
OTX-015 |
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OTX015 is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4. Phase 1. |
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898044-15-0 |
PF-3758309 |
more... |
PF-3758309 is an orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-3758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival. |
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244767-67-7 |
Dapivirine(TMC-120) |
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Dapivirine (TMC120) is a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM, inhibits a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. Phase 3. |
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924416-43-3 |
AdipoRon |
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AdipoRon is a novel, and orally bioavailable adiponectin receptor agonist with KD of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively. |
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