CAS NO. |
Products Name |
1352226-88-0 |
AZD6738 |
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AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells. |
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1229194-11-9 |
Edoxaban |
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Edoxaban is a selective factor Xa inhibitor with Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa, and is also an orally bioavailable anticoagulant drug. |
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1626387-80-1 |
AZD3759 |
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AZD3759 is a potent, oral active, CNS-penetrant EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. |
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1401033-86-0 |
AMG 925 |
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AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. |
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1608125-21-8 |
AMG319 |
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AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks |
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1620576-64-8 |
AZD8835 |
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AZD8835 is an effective and selective PI3K inhibitors of PI3K and δ α, the IC50 values were 5.7 and 6.2 nM nM, selective than the PI3K-beta (IC50 to 431 nM) and PI3K gamma (IC50 for 90 nM). |
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