CAS NO. |
Products Name |
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1051375-10-0 |
Cabotegravir (GSK1265744) |
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Cabotegravir is a potent HIV integrase inhibitor as an oral lead-in tablet and long-acting injectable for the treatment and prevention of HIV infection. Cabotegravir is an inhibitor of OAT1 (IC50 0.81 μM) and OAT3 (IC50 0.41 μM). |
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1793053-37-8 |
LLY-507 |
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LLY-507 is a potent inhibitor of SMYD2 with IC50 < 15 nM, is >100-fold selective for SMYD2 over a broad range of methyltransferase and non-methyltransferase targets. |
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875320-29-9 |
Quisinostat (JNJ-26481585) |
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Quisinostat is an orally available, potent, hydroxamate, pan-HDACi with broad activity in solid and hematologic tumor models. Quisinostat inhibits HDAC1 (IC50 = 0.11 nM), HDAC2 (IC50 = 0.33 nM), HDAC4 (IC50 = 0.64 nM), HDAC10 (IC50 = 0.46 nM), HDAC11 (IC50 = 0.37 nM). |
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65101-87-3 |
Nanchangmycin |
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Nanchangmycin is a polyether antibiotic and is very active against a broad spectrum of harmful nematodes and insects but not for mammals and plants. |
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1229705-06-9 |
RG7388 |
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RG7388 is an oral, selective, small molecule MDM2 antagonist that inhibits binding of MDM2 to p53. |
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1687736-54-4 |
SGC707 |
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SGC707 is a first-in-class PRMT3 chemical probe which is a potent, selective, and cell-active allosteric inhibitor of PRMT3 with IC50 of 31 nM. |
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1338247-30-5 |
BMS-3 |
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BMS-3 is a potent inhibitor of LIMK1.LIM kinase 1 (LIMK1) activity is essential for cell migration and cell cycle progression. |
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1338247-35-0 |
BMS-5 |
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BMS-5 is a Potent LIM kinase inhibitor (IC50 values are 7 and 8 nM for LIMK1 and LIMK2 respectively).Inhibits cofilin phosphorylation in MDA-MB-231 breast cancer cells. |
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1369764-02-2 |
Lemborexant |
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Lemborexant is a dual antagonist of the orexin OX1 and OX2 receptors which is under development for treatment of insomnia. |
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