CAS NO. |
Products Name |
162520-00-5 |
Salirasib |
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Salirasib is a potent competitive prenylated protein methyltransferase (PPMTase) inhibitor with Ki of 2.6 μM, which inhibits Ras methylation. Phase 2. |
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1262618-39-2 |
GS967 |
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GS967 is a novel, potent, and selective inhibitor of cardiac late sodium current(late INa); inhibits ATX-II-induced late I(Na) in ventricular myocytes and isolated hearts with IC(50) values of 0.13 and 0.21 μM, respectively. |
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1300031-52-0 |
GSK1324726A (I-BET726) |
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GSK1324726A (I-BET726) is a novel, potent, and selective small molecule inhibitor of BET proteins with high affinity to BRD2 (IC50= 41 nM), BRD3 (IC50= 31 nM), and BRD4 (IC50= 22 nM). |
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953769-46-5 |
BLZ945 |
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BLZ945 is a highly selective and brain-penetrant inhibitor of CSF1R with IC50 of 1 nM; >3200-fold higher than its affinity for other kinases. |
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1527473-33-1 |
PF-06447475 |
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PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively. |
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218600-53-4 |
Bardoxolone Methyl |
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Bardoxolone methyl(RTA 401; NSC 713200) is the lead molecule in Reata's portfolio of Antioxidant Inflammation Modulators (AIMs). The AIMs are potent inducers of the transcription factor Nrf2. |
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219766-25-3 |
ANA-12 |
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ANA-12 is a potent and selective TrkB antagonist with anxiolytic and antidepressant activity in mice. |
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1191911-27-9 |
CZC-54252 |
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CZC-54252 is a potent inhibitor of LRRK2 with IC50s of 1.28 nM and 1.85 nM for wild-type and G2019S LRRK2 respectively. |
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