CAS NO. |
Products Name |
1818885-28-7 |
ARV-825 |
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ARV-825 is a BRD4 inhibitor with DC50 (50% of maximum degradation) <1nM for Burkitt's lymphoma (BL) cell lines. Affinity to BD1 and BD2 of BRD4 by ARV-825 is 90 and 28 nM, respectively. |
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376348-65-1 |
Maraviroc |
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Maraviroc (UK-427857; Selzentry; Celsentri) is a selective CCR5 antagonist (IC50= 6.4 nM); displays potent anti-HIV-1 activity. |
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1125758-85-1 |
A804598 |
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A-804598 is a novel, competitive, and selective P2X7 receptor antagonist with IC50 of 10 nM, 9 nM and 11 nM in rat, mouse and human P2X7 receptors respectively. |
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374913-63-0 |
Madrasin |
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Madrasin is a potent and cell penetrant splicing inhibitor that interferes with the early stages of spliceosome assembly. |
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1224846-01-8 |
MK3697 |
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MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. |
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349085-38-7 |
HC-030031 |
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HC-030031 is a selective TRPA1 channel blocker that antagonizes AITC- and formalin-evoked calcium influx with IC50 of 6.2 μM and 5.3 μM respectively. |
|
171500-79-1 |
Dalbavancin HCL |
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Dalbavancin(BI-397; MDL-63397) is a semisynthetic lipoglycopeptide, has potent activity against Gram-positive bacteria(MIC50=0.06 mg/L; B. anthracis). |
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200626-61-5 |
ITSA-1(ITSA1) |
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ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but not other HDAC inhibitors. |
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1415716-58-3 |
TG6-10-1 |
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TG6-10-1 is an EP2 antagonist, shows low-nanomolar antagonist activity against only EP2, >300-fold selectivity over human EP3, EP4, and IP receptors, 100-fold selectivity over EP1 receptors. |
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873652-48-3 |
GDC0152 |
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GDC-0152 is a potent inhibitor of IAPs; binds to the XIAP BIR3 domain, the BIR domain of ML-IAP, and the BIR3 domains of cIAP1 and cIAP2 with K(i) values of 28, 14, 17, and 43 nM, respectively. |
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127191-97-3 |
KN62 |
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KN-62 is selective, cell-permeable inhibitor of CaM kinase II (IC50 = 0.9 μM); binds directly to the calmodulin binding site of the enzyme; potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM). |
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