CAS NO. |
Products Name |
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1286770-55-5 |
MK8931 |
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FRAX486是group I PAKs有效选择性抑制剂,对PAK1、PAK2和PAK3的IC50值分别为8.25nM、39.5nM和55.3nM,对PAK4的抑制力弱(IC50=779nM)。 |
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1236199-60-2 |
EDO-S101 |
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EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. |
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1182367-47-0 |
RAD-140 |
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RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM). IC50 value: 7 nM (Ki, fot androgen receptor) [1] Target: androgen receptor in vitro: RAD140 demonstrates excellent affinity for the androgen receptor (Ki = 7 nM) as well as good selectivity over other steroid hormone nuclear receptors, with the closest off target receptor being the progesterone receptor (IC50 = 750 nM). [1] RAD140 is a novel SARM with high affinity and specificity for AR, is orally available, and exhibits potent anabolic effects in rodents and nonhuman primates.[2] in vivo: The stability of RAD140 is high (t1/2 > 2 h) in incubations with rat, monkey, and human microsomes, and it also had good bioavailability in rats and monkeys. [1] RAD140 is also neuroprotective using the rat kainate lesion model. RAD140 is shown to exhibit peripheral tissue-specific androgen action that largely spared prostate, neural efficacy by activation of androgenic gene regulation effects, and neuroprotection of hippocampal neurons against cell death caused by systemic administration of the excitotoxin kainate.[2 |
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1523406-39-4 |
SAR405 |
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SAR405 is highly potent and selective inhibitor of PIK3C3 with an IC50 of 27 nM. SAR405 treatment inhibits autophagy induced either by starvation or by MTOR (mechanistic target of rapamycin) inhibition.Combining SAR405 with everolimus, the FDA-approved MTOR inhibitor, results in a significant synergy on the reduction of cell proliferation using renal tumor cells |
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1708971-55-4 |
FGF401 |
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FGF-401 is an inhibitor of FGFR4 extracted from patent WO2015059668A1, compound example 83; has an IC50 of 1.9 nM |
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1320346-97-1 |
GLPG0187 |
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GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM. |
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2083627-02-3 |
EED226 |
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EED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM. |
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1323403-33-3 |
EED226 |
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Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay |
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1323403-33-3 |
CC220 |
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Iberdomide (CC-220) is a cereblon modulator in clinical development for systemic lupus erythematosis. Iberdomide exhibits an IC50 of 60 nM in TR-FRET cereblon binding assay |
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545395-94-6 |
AMG9810 |
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AMG9810 is a selective and competitive vanilloid receptor 1 (TRPV1) antagonist with IC50 values of 24.5 and 85.6 nM for human and rat TRPV1, repectively |
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