| CAS NO. |
Products Name |
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| 344458-15-7 |
PJ34(HCL) |
more... |
| PJ34 HCl is the hydrochloride salt of PJ34, which is a PARP inhibitor with EC50 of 20 nM and is equally potent to PARP1/2. |
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| 868540-17-4 |
Carfilzomib(PR171) |
more... |
| Carfilzomib (PR-171) is an irreversible proteasome inhibitor with IC50 of <5 nM, displayed preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, but little or no effect on the PGPH and T-L activities. |
|
| 459868-92-9 |
Rucaparib(AG-014699) |
more... |
| Rucaparib (AG-014699, PF-01367338) is an inhibitor of PARP with Ki of 1.4 nM for PARP1, also showing binding affinity to eight other PARP domains. Phase 3. |
|
| 133407-82-6 |
MG132 |
more... |
| MG-132 is an inhibitor of proteasome with IC50 of 100 nM, and also inhibits calpain with IC50 of 1.2 μM. |
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| 1207456-01-6 |
BMN673 |
more... |
| BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM. It is also a potent inhibitor of PARP-2, but does not inhibit PARG and is highly sensitive to PTEN mutation. Phase 3. |
|
| 934162-61-5 |
A-966492 |
more... |
| A-966492 is a novel and potent inhibitor of PARP1 and PARP2 with Ki of 1 nM and 1.5 nM, respectively. |
|
| 1072833-77-2 |
MLN2238 |
more... |
| MLN2238(Ixazomib) inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with IC50 and Ki of 3.4 nM and 0.93 nM, respectively. |
|
| 1201902-80-8 |
MLN9708 |
more... |
| MLN9708 immediately hydrolyzed to MLN2238, which is an N-capped dipeptidyl leucine boronic acid and preferentially bound to and inhibited the 20S proteasome with an IC50 value of 3.4 nM (Ki = 0.93 nM). |
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