CAS NO. |
Products Name |
220904-83-6 |
GW5074 |
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GW5074 is a potent and selective c-Raf inhibitor with IC50 of 9 nM, no effect on the activities of JNK1/2/3, MEK1, MKK6/7, CDK1/2, c-Src, p38 MAP, VEGFR2 or c-Fms is noted |
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1216665-49-4 |
APY29 |
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APY29 are IRE1 allosteric modulators of Alpha, IRE1-Alpha phosphorylation, the IC50 for 280 nM, activated IRE1-Alpha activity of RNase. |
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960203-27-4 |
Vortioxetine (Lu AA21004) |
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Vortioxetine (Lu AA21004) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with IC50 of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. |
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1073485-20-7 |
LDC000067 |
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LDC000067 is a highly selective CDK9 inhibitor with IC50 of 44 nM, 55/125/210/ >227/ >227-fold selectivity over CDK2/1/4/6/7. |
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950762-95-5 |
PCI-34051 |
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PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10. |
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1238697-26-1 |
TAK-063 |
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TAK-063 is a selective PDE10A efficient inhibitors, an orally active, PDE10A IC50 values for 0.3nM, no effects on other PDEs. |
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1000998-59-3 |
BMS-687453 |
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BMS-687453 is an effective and selective PPAR-Alpha agonist, on human PPAR-α, the EC50 for 10 nM, 410 times times higher than on human selective PPAR gamma. |
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