| CAS NO. |
Products Name |
| 134381-21-8 |
Epoxomicin |
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| Epoxomicin(BU-4061T) is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome. |
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| 1624602-30-7 |
VR23 |
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| VR23 is a small molecule that potently inhibited the activities of trypsin-like proteasomes (IC50 = 1 nM), chymotrypsin-like proteasomes (IC50 = 50-100 nM), and caspase-like proteasomes (IC50 = 3 μM). |
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| 1645286-75-4 |
AZ6102 |
more... |
| AZ6102 is a potent TNKS1/2 inhibitor (IC50=3/1 nM) that has 100-fold selectivity against other PARP family enzymes (IC50: 0.5-3 μM) and shows 5 nM Wnt pathway inhibition in DLD-1 cells. |
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| 1038915-60-4 |
MK4827 (Niraparib) |
more... |
| MK-4827(Niraparib) is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1. |
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| 328543-09-5 |
AG14361 |
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| AG14361 is a potent inhibitor of PARP1 with Ki of <5 nM. It is at least 1000-fold more potent than the benzamides. |
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| 179528-45-1 |
PD150606 |
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| PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor (Ki values for ν and m-calpains are 0.21 and 0.37 μM respectively). |
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| 66611-37-8 |
BGP-15 |
more... |
| BGP-15 is a PARP inhibitor, that can protect against heart failure and atrial fibrillation in mice. |
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| 1262417-51-5 |
NMS-P118 |
more... |
| NMS-P118 is a potent, orally available, and highly selective PARP-1 Inhibitor for cancer therapy with an IC50 of 0.04 μM in HeLa cell. |
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| 415903-37-6 |
Grapiprant |
more... |
| Grapiprant is a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). Target: prostaglandin receptor in vitro: Grapiprant is a novel pharmacologically active ingredient, acts as a selective EP4 receptor antagonist whose physiological ligand is prostaglandin E2 (PGE2). [1] in vivo: Grapiprant is currently under development for use in humans and dogs for the control of pain and inflammation associated with osteoarthritis. [1] Results suggested the safety of long-term oral administration of grapiprant to dogs. Efficacy of grapiprant in the treatment of dogs with osteoarthritis needs to be evaluated in other studies. [ |
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