CAS NO. |
Products Name |
503068-34-6 |
Vilanterol(GW642444) |
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Vilanterol (GW642444; GW 642444X) is a novel, inhaled, long-acting β(2) agonist with inherent 24-h activity under development as a once-daily combination therapy with an inhaled corticosteroid for COPD and asthma. |
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571170-77-9 |
MK-0524(Laropiprant) |
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Laropiprant(MK 0524) is a potent, selective DP1 receptor antagonist with Ki value of 0.57 nM; exhibits >1,000 fold selectivity over DP2 receptor (Ki=0.75 uM). IC50 value: 0.57 nM/0.75 uM (Ki for DP1/DP2) |
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315183-21-2 |
PAC-1 |
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PAC 1 is a procaspase-activating compound, which in turn produces caspase-3 (EC50 = 0.22 μM). PAC 1 also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). |
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1431697-89-0 |
OTSSP167 |
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OTSSP167 is a highly potent MELK (maternal embryonic leucine zipper kinase) inhibitor with IC50 of 0.41 nM. |
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1620401-82-2 |
UNC-0379 |
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UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15 other methyltransferases. |
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1429881-91-3 |
UNC2025 |
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UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3 |
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940929-33-9 |
SB743921 |
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SB-743921 is a second generation, highly potent and active KSP inhibitor with Ki of 0.1 nM; no affinity to MKLP1, Kin2, Kif1A, Kif15, KHC, Kif4 and CENP-E. |
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336113-53-2 |
Ispinesib(SB-715992) |
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Ispinesib is a potent, specific and reversible inhibitor of KSP (HsEg5) with Ki of 1.7 nM. Ispinesib is a synthetic small molecule, derived from quinazolinone, with antineoplastic properties. |
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1088965-37-0 |
GSK923295 |
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GSK923295 is a first-in-class, specific allosteric inhibitor of CENP-E kinesin motor ATPase with Ki of 3.2 nM, and less potent to mutant I182 and T183. |
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